dr. S.M. (Stefan) Willems

Associate Professor - medical

  • Department of Pathology

Research Programs


Dr Stefan Willems was trained in medicin (2003 cum laude Catholic University Leuven) with a PhD in molecular pathology (2010, Leiden University) and specialized in pathology (2011, LUMC). After postdoc positions at Harvard Medical School (Gygilab) and NKI  (Bernardslab) he has been working as a pathologist with special interest in molecular pathology and diagnostics. He is co-director of the molecular pathology lab in the University Medical Center Utrecht. He is associate professor in pathology and head of the molecular head and neck cancer line within the UMC Utrecht (1 postdoc, 8 PhDs). He is also affiliated with the department of pathology of the NKI-AvL and performs here translational head and neck research. He is board member of the PALGA Foundation.

Research Output (147)

Digital pathology-aided assessment of tumor-infiltrating T lymphocytes in advanced stage, HPV-negative head and neck tumors

de Ruiter Emma J, de Roest Reinout H, Brakenhoff Ruud H, Leemans C René, de Bree Remco, Terhaard Chris H J, Willems Stefan M 24 jan 2020, In: Cancer Immunology, Immunotherapy. 69 , p. 581-591 11 p.

High CXCR4 expression in adenoid cystic carcinoma of the head and neck is associated with increased risk of locoregional recurrence

Klein Nulent Thomas J W, van Es Robert J J, Valstar Matthijs H, Smeele Ludwig E, Smit Laura A, Klein Gunnewiek Raquel, Zuithoff Nicolaas P A, de Keizer Bart, de Bree Remco, Willems Stefan 16 jan 2020, In: Journal of Clinical Pathology. 73 , p. 476-482 7 p.

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy

Driehuis Else, Spelier Sacha, Beltrán Hernández Irati, de Bree Remco, M Willems Stefan, Clevers Hans, Oliveira Sabrina 5 nov 2019, In: Journal of Clinical medicine. 8

The potential use of big data in oncology

Willems Stefan M, Abeln Sanne, Feenstra K Anton, de Bree Remco, van der Poel Egge F, Baatenburg de Jong Robert J, Heringa Jaap, van den Brekel Michiel W M 12 sep 2019, In: Oral Oncology. 98 , p. 8-12 5 p.

Comparison of three PD-L1 immunohistochemical assays in head and neck squamous cell carcinoma

de Ruiter E., Mulder F., Speel E., van den Hout M., de Roest R., Bloemena E., Devriese L., Willems S. sep 2019, In: Virchows Archiv. 475 , p. S90-S91

Update on Neuroendocrine Carcinomas of the Larynx

Strosberg Carolina, Ferlito Alfio, Triantafyllou Asterios, Gnepp Douglas R, Bishop Justin A, Hellquist Henrik, Strojan Primoz, Willems Stefan M, Stenman Göran, Rinaldo Alessandra, Hernandez-Prera Juan C 15 aug 2019, In: American journal of clinical pathology. 152 , p. 686-700 15 p.

Prognostic value of the nodal yield in head and neck squamous cell carcinoma:A systematic review

de Kort Willem W B, Maas Sybren L N, Van Es Robert J J, Willems Stefan M aug 2019, In: Head & neck. 41 , p. 2801-2810 10 p.

Well-differentiated Neuroendocrine Carcinoma of the Larynx:Confusion of Terminology and Uncertainty of Early Studies

Hunt Jennifer L, Barnes Leon, Triantafyllou Asterios, Gnepp Douglas R, Devaney Kenneth O, Stenman Göran, Halmos Gyorgy B, Bishop Justin A, Skálová Alena, Willems Stefan M, Hellquist Henrik, Rinaldo Alessandra, Ferlito Alfio 1 jul 2019, In: Advances in anatomic pathology. 26 , p. 246-250 5 p.

Depth of invasion in patients with early stage oral cancer staged by sentinel node biopsy

den Toom Inne J., Janssen Luuk M., van Es Robert J.J., Karagozoglu K. Hakki, de Keizer Bart, van Weert Stijn, Willems Stefan M., Bloemena Elisabeth, Leemans C. René, de Bree Remco 1 jul 2019, In: Head and Neck. 41 , p. 2100-2106 7 p.

High rate of unexpected lymphatic drainage patterns and a high accuracy of the sentinel lymph node biopsy in oral cancer after previous neck treatment

den Toom Inne J, Boeve Koos, van Weert Stijn, Bloemena Elisabeth, Brouwers Adrienne H, Hoekstra Otto S, de Keizer Bart, van der Vegt Bert, Willems Stefan M, Leemans C René, Witjes Max J H, de Bree Remco jul 2019, In: Oral Oncology. 94 , p. 68-72 5 p.

All Research Output (147)