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dr. J.R. (Janneke) Zinkstok

Assistant Professor - medical
dr. J.R. (Janneke) Zinkstok
  • Psychiatry

Biography

Biography

Dr. Janneke Zinkstok trained as a Medical Doctor and subsequently as a Psychiatrist in Amsterdam, the Netherlands, and completed a PhD in Psychiatric Genetics (University of Amsterdam). She worked as a Clinical Research Fellow in the Institute of Psychiatry, King’s College London, where she studied brain structure in Autism Spectrum Disorders, and specialized in developmental disorders in adults at the Maudsley Hospital. She is now a Psychiatrist at the Department of Psychiatry at the UMC Utrecht, The Netherlands. Her clinical and research interests include the neurobiology of brain development and psychiatric disorders especially neurodevelopmental disorders (ADHD and autism) and psychosis, and 22q11.2 deletion syndrome.

Key publications

  1. Zinkstok, J, Boot, E, Bassett, AS, Hiroi, N, Butcher, NJ, Vingerhoets, C, Vorstman, JAS, & van Amelsvoort, TAMJ. The 22q11.2 deletion syndrome from a neurobiological perspective. 2019, in press Lancet Psychiatry.

  2. Boer J, Boot E,  van Gils L, van Amelsvoort T, Zinkstok J.  Adverse effects of antipsychotic medication in patients with 22q11.2 deletion syndrome: A systematic review. in press American Journal of Medical Genetics Part A.
  3. Boer J, Vingerhoets C, Hirdes M, McAlonan GM, Amelsvoort T, Zinkstok J. Efficacy and tolerability of riluzole in psychiatric disorders: a systematic review and preliminary meta-analysis. Psychiatry Research 2019 Aug; 278:294-302.
  4. Ajram L, Horder J, Mendez M, Galanopoulos A, Brennan L, Wichers R, Robertson D, Murphy C, Zinkstok J, Ivin G, Heasman M, Meek D, Tricklebank M, Barker G, Lythgoe D, Edden R, Williams SC, Murphy D, McAlonan G. Shifting prefrontal Excitation-Inhibition balance and functional connectivity in Autism Spectrum Disorder. Translational Psychiatry 2017 May 23;7(5):e1137.
  5. Wilson CE, Murphy CM, McAlonan G, Robertson DM, Spain D, Hayward H, Woodhouse E, Deeley PQ, Gillan N, Ohlsen JC, Zinkstok J, Stoencheva V, Faulkner J, Yildiran H, Bell V, Hammond N, Craig MC, Murphy DG. Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Autism 2016 Oct;20(7):808-19.
  6. Russell AJ, Murphy CM, Wilson E, Gillan N, Brown C, Robertson DM, Craig MC, Deeley Q, Zinkstok J, Johnston K, McAlonan GM, Spain D, Murphy DG. The mental health of individuals referred for assessment of autism spectrum disorder in adulthood: A clinic report. Autism 2015 Jul;20(5):623-7.
  7. Deoni S & Zinkstok J [joint first authors], Daly E, Johnston P, Ecker C, AIMS Consortium, Murphy D.  Is brain myelination altered in autism? An in vivo MRI study. Psychological Medicine 2015, 45(4):795-805.
  8. Wilson C, Gillan N, Spain D, Robertson D, Roberts G, Murphy CM, Maltezos S, Zinkstok J, Johnston K, Dardani C, Ohlsen C, Deeley P, Craig M, Mendez M, Happé F, Murphy D.  Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic. J Autism Dev Disord 2013, 43(11):2515-25.
  9. Raux G, Bumsel E, Hecketsweiler B, van Amelsvoort T, Zinkstok J, Manouvrier-Hanu S, Fantini C, Breviere GM, Di Rosa G, Pustorino G, Vogels A, Swillen A, Legallic S, Bou J, Opolczynski G, Drouin-Garraud V, Lemarchand M, Philip N, Gerard-Desplanches A, Carlier M, Philippe A, Nolen MC, Heron D, Sarda P, Lacombe D, Coizet C, Alembik Y, Layet V, Afenjar A, Hannequin D, Demily C, Petit M, Thibaut F, Frebourg T, Campion D. Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome. Human Molecular Genetics 2007, 1;16(1):83-91.
  10. Zinkstok J, van Amelsvoort T. Neuropsychological profile and neuroimaging in patients with 22q11.2 Deletion Syndrome: a review. Child Neuropsychology 2005, 1: 21-37.

Research Output (33)

Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers:A randomized double-blind 7-Tesla pharmacological MRS study

Vingerhoets Claudia, Tse Desmond Hy, van Oudenaren Mathilde, Hernaus Dennis, van Duin Esther, Zinkstok Janneke, Ramaekers Johannes G, Jansen Jacobus Fa, McAlonan Grainne, van Amelsvoort Therese 25 mei 2020, In: Journal of Psychopharmacology. 34 , p. 856-863 8 p.

Van genetische bevindingen naar de klinische praktijk van de psychiater:hoe genetica precisiepsychiatrie mogelijk kan maken

Schijven D., Zinkstok J. R., Luykx J. J. 2020, In: Tijdschrift voor Psychiatrie. 62 , p. 776-783 8 p.

Psychose en bewegingsstoornissen bij een adolescent met 22q11.2-deletiesyndroom

Zinkstok J R, Velders F, Rieken R, Houben M, Fiksinski A, van Amelsvoort T A M J, Boot E 2020, In: Tijdschrift voor Psychiatrie. 62 , p. 229-233 5 p.

Beloop van covid-19-infecties en impact op mentale gezondheid; opzet van een landelijk casusregister

Van Helvoort Marloes, Van Dee Violet, Dirks Astrid, Everaerd Daphne, Metz Margot, Van Schijndel Maarten, Tendolkar Indira, Zinkstok Janneke, Cahn Wiepke, Schellekens Arnt 2020, In: Tijdschrift voor Psychiatrie. 62 , p. 739-742 4 p.

Atypical chromosome 22q11.2 deletions are complex rearrangements and have different mechanistic origins

Vervoort Lisanne, Demaerel Wolfram, Rengifo Laura Y, Odrzywolski Adrian, Vergaelen Elfi, Hestand Matthew S, Breckpot Jeroen, Devriendt Koen, Swillen Ann, McDonald-McGinn Donna M, Fiksinski Ania M, Zinkstok Janneke R, Morrow Bernice E, Heung Tracy, Vorstman Jacob A S, Bassett Anne S, Chow Eva W C, Shashi Vandana, Vermeesch Joris R, 15 nov 2019, In: Human Molecular Genetics. 28 , p. 3724-3733 10 p.

Neurobiological perspective of 22q11.2 deletion syndrome

Zinkstok Janneke R., Boot Erik, Bassett Anne S., Hiroi Noboru, Butcher Nancy J., Vingerhoets Claudia, Vorstman Jacob A.S., van Amelsvoort Therese A.M.J. 1 nov 2019, In: The Lancet Psychiatry. 6 , p. 951-960 10 p.

ASSESSING CAUSAL LINKS BETWEEN METABOLIC TRAITS, INFLAMMATION AND SCHIZOPHRENIA: A UNIVARIABLE AND MULTIVARIABLE BIDIRECTIONAL MENDELIAN RANDOMIZATION STUDY

Lin Bochao, Alkema Anne, Zinkstok Janneke, Lars Libuda, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Roger Adan, Luykx Jurjen okt 2019, In: European Neuropsychopharmacology. 29 , p. S211-S211

Assessing causal links between metabolic traits, inflammation and schizophrenia:a univariable and multivariable, bidirectional Mendelian-randomization study

Lin Bochao D., Alkema Anne, Peters Triinu, Zinkstok Janneke, Libuda Lars, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Adan Roger, Luykx Jurjen J. 31 aug 2019, In: International Journal of Epidemiology. 48 , p. 1505-1514 10 p.

Adverse effects of antipsychotic medication in patients with 22q11.2 deletion syndrome:A systematic review

de Boer Janna, Boot Erik, van Gils Lissa, van Amelsvoort Therese, Zinkstok Janneke 13 aug 2019, In: American Journal of Medical Genetics. Part A. 179 , p. 2292-2306 15 p.

Efficacy and tolerability of riluzole in psychiatric disorders:A systematic review and preliminary meta-analysis

de Boer J. N., Vingerhoets C., Hirdes M., McAlonan G. M., Arnelsvoort T. V., Zinkstok J. R. 21 jun 2019, In: Psychiatry Research. 278 , p. 294-302 9 p.

All research output

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