dr. H.M. (Hanneke) van Santen

dr. H.M. (Hanneke) van Santen

Associate Professor - medical
dr. H.M. (Hanneke) van Santen
  • Endocrinology patient care

Research Programs



Dr. H.M. van Santen is clinical researcher, pediatric endocrinologist, and committed to improve the endocrine outcome of children with (oncologic) disease.

"I have the vision that all children should have an optimal hormonal state enabling them to have an optimal daily quality of life and to develop and grow (comparable to their peers) into adulthood. For children with underlying disease, this requires cross-field thinking and collaboration with partners outside of one’s own domain. My mission is to improve outcome of children with any kind of disease by preventing or restoring their endocrine dysfunction. Within this mission, I focus on the key-player of the endocrine system; “the hypothalamus".

Dr. Van Santen moved her career in 2013 to Utrecht to coordinate the endocrine care for children with cancer in the Princess Máxima Center. She has co-authored > 150 papers on the endocrine effects of childhood cancer treatment, pediatric thyroid cancer , craniopharyngioma and hypothalamic dysfunction.

She is an active associate professor in the research program of Child Health, WKZ, UMCU and associate-PI in the Princess Máxima Centre for Pediatric Oncology. In the UMCU Utrecht, she is coordinator of the European Reference Centers for "Rare Hypothalamic Disease", "Pituitary tumors" and "Thyroid Tumors" and , within the Maxima, chair of the M4C Craniopharyngioma. Her research program focusses on hypothalamic dysfunction and hypothalamic obesity, craniopharyngioma, pediatric thyroid cancer and the endocrine effects of childhood cancer treatment. She is an internationally acknowledged expert on hypothalamic dysfunction and pediatric thyroid cancer with regular invited lectures both national and international.

She is the chair of the Dutch Pediatric Endocrinologists (NvK, sectie kinderendocrinologie), of the SIOPe craniopharyngioma working group, and of the European Guideline for Thyroid cancer in children. Together with the Late Effects of Childhood Cancer International Guideline Harmonization Groups (IGHG) she co-chairs the recommendations for thyroid and hypothalamic-pituitary disorders, and is member of the working groups for gonadal toxicity and preservation of fertility and metabolic syndrome.

Side Activities

2020 - now   member of the WKZ Onderzoeksfonds Scientific Committee

2020             member of the Internal Grant committee Princess Maxima Center

2020             Chair SIOPe craniopharyngioma board

2020             Member of the Advisory board of the Academic Japanese Consortium for Juvenile Thyroid Cancer (JCJTC, president Dr Ohtsuru)  

2020             co-PI Prinses Maxima Center for Pediatric Oncology Utrecht

2019             BKO qualification UMCU

2019             Chair of the European Task Force for Recommendations of Treatment of Thyroid nodules and Carcinoma in Childhood

2016 – now  Deputy educator ( plaatsvervangend opleider) of the clinical fellow pediatric endocrinology in the Wilhelmina Children’s Hospital, UMCU

2018 - now   member of working group supportive care Princess Maxima Center

2017 - now   member of fertility working group Princess Maxima Center

2016 - now   Co-chair of the IGHG for surveillance of hypothalamic-pituitary disorders in Childhood Cancer Survivors

2016 - now   Participant/ member of the working group of the IGHG working group for  preservation of fertility in male childhood cancer survivors (in progress)

2016 – now  Participant / working group lead of the IGHG working group for preservation of fertility in female childhood cancer survivors (in progress)

2016 - now   Participant/ member of the working group of the IGHG recommendation for surveillance of the metabolic syndrome in childhood cancer survivors (in progress)

2016 - now   Co-chair of the Dutch Guideline for Treatment of Thyroid nodules and cancer in children (in progress)

2016 - now   Participant of  the SIOP supportive care group

2016 - now   Participant of the SIOP low grade glioma working group

2016 - now   Participant of the national consortium for Late effects of treatment for childhood thyroid carcinoma ( PI T Links, UMCG)

2016 - now   Participant of the consortium of the Dexadagen-2 study

2015 - now   Participant of the Dutch Growth Hormone Advisory board (SEK)

2015 - now   Consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma(

 2015 – now    Participant of the SKION LATER Recommendations for screening Childhood Cancer Survivors


Fellowship and Awards

2020                ZonMW Stimuleringssubsidie "Implementatie van nieuw behandelalgoritme voor hypothalame obesitas bij kinderen met een supra-sellaire tumor"

2019                KIKA project: THYRO-Dynamics Study (Prospective study on thyroid function during treatment with chemotherapy in 600 children)

2019                Princess Maxima Grant; research grant for 4-year PhD student: “Building an organoid model for craniopharyngioma”

2009-2011      Fellowship kinderendocrinologie in het Emma Kinderziekenhuis AMC

Research Output (177)

Feasibility, safety, and efficacy of dietary or lifestyle interventions for hypothalamic obesity:A systematic review

Van Roessel I. M.A.A., Van Den Brink M., Dekker J., Ruitenburg-van Essen B. G., Tissing W. J.E., van Santen H. M. Aug 2024, In: Clinical Nutrition. 43 , p. 1798-1811 14 p.

Overview of European standard clinical practice recommendations for multidiscplinary teams involved in the treatment of central nervous system tumours in children and adolescents – SIOPE Brain Tumour Group

Otth Maria, Scheinemann Katrin, Ajithkumar Thankamma, Aquilina Kristian, Avula Shivaram, Gan Hoong Wei, Janssens Geert O., Lemiere Jurgen, Morana Giovanni, Opocher Enrico, Pfister Stefan M., Porro Giorgio, Sahm Felix, Thomale Ulrich Wilhelm, van Egmond-Ebbeling Michelle, van Santen Hanneke M., Pizer Barry, Rutkowski Stefan Jun 2024, In: EJC Paediatric Oncology. 3 11 p.

The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations

Irestorm Elin, Schouten-van Meeteren Antoinette Y.N., van Gorp Marloes, Twisk Jos W.R., van Santen Hanneke M., Partanen Marita, Grootenhuis Martha A., van Litsenburg Raphaele R.L. 2 May 2024, In: Pediatric Blood and Cancer. 71

The cumulative burden of self-reported, clinically relevant outcomes in long-term childhood cancer survivors and implications for survivorship care:A DCCSS LATER study

Streefkerk Nina, Teepen Jop C., Feijen Elizabeth A.M., Jóźwiak Katarzyna, van der Pal Helena J.H., Ronckers Cecile M., De Vries Andrica C.H., Van der Heiden-van Der Loo Margriet, Hollema Nynke, van den Berg Marleen, Loonen Jacqueline, Grootenhuis Martha A., Bresters Dorine, Versluys A. Brigitta, van Dulmen-den Broeder Eline, van den Heuvel-Eibrink Marry M., van Leeuwen Flora E., Neggers Sebastian J.C.M.M., Van Santen Hanneke M., Hawkins Mike, Hauptmann Michael, Yoneoka Daisuke, Korevaar Joke C., Tissing Wim J.E., Kremer Leontien C.M. 15 Apr 2024, In: Cancer. 130 , p. 1349-1358 10 p.

BMI increase during early childhood in boys with cystic fibrosis and early adrenarche

Tamer Gizem, Arets Hubertus Gerardus Maria, van der Ent Cornelis Kors, van Santen Hanneke Margo, van der Kamp Hetty Jacoba 25 Jan 2024, In: Pediatric Pulmonology. 59 , p. 991-996 6 p.

A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test

Touwslager Robbert N.H., Michel Zwaan C., Bakker Boudewijn, Lentjes Eef G.W.M., Looijenga Leendert H.J., van Santen Hanneke M. 2024, In: Journal of Pediatric Endocrinology & Metabolism. 37 , p. 482-485 4 p.

Author Correction:A joint international consensus statement for measuring quality of survival for patients with childhood cancer

van Kalsbeek Rebecca J, Hudson Melissa M, Mulder Renée L, Ehrhardt Matthew, Green Daniel M, Mulrooney Daniel A, Hakkert Jessica, den Hartogh Jaap, Nijenhuis Anouk, van Santen Hanneke M, Schouten-van Meeteren Antoinette Y N, van Tinteren Harm, Verbruggen Lisanne C, Conklin Heather M, Jacola Lisa M, Webster Rachel Tillery, Partanen Marita, Kollen Wouter J W, Grootenhuis Martha A, Pieters Rob, Kremer Leontien C M, 14 Nov 2023, In: Nature Medicine. 30 , p. 603

Prevalence, risk factors and optimal way to determine overweight, obesity and morbid obesity, in the first Dutch cohort of 2,338 long-term survivors of childhood cancer:a DCCSS-LATER study

Pluimakers V G, van Atteveld J E, de Winter D T C, Bolier M, Fiocco M, Nievelstein R A J, Janssens G O R, Bresters D, van der Heiden-van der Loo M, de Vries A C H, Louwerens M, van der Pal H J, Pluijm S M F, Ronckers C M, Versluijs A B, Kremer L C M, Loonen J J, van Dulmen-den Broeder E, Tissing W J E, van Santen H M, van den Heuvel-Eibrink M M, Neggers S J C M M 14 Oct 2023, In: European Journal of Endocrinology. 189 , p. 495-507 13 p.

Tocilizumab for the fifth progression of cystic childhood craniopharyngioma-a case report

de Vos-Kerkhof Evelien, Buis Dennis R, Lequin Maarten H, Bennebroek Carlien A, Aronica Eleonora, Hulleman Esther, Zwaveling-Soonawala Nitash, van Santen Hanneke M, Schouten-van Meeteren Antoinette Y N 11 Oct 2023, In: Frontiers in Endocrinology. 14

Pediatric body composition based on automatic segmentation of computed tomography scans:a pilot study

Samim Atia, Spijkers Suzanne, Moeskops Pim, Littooij Annemieke S, de Jong Pim A, Veldhuis Wouter B, de Vos Bob D, van Santen Hanneke M, Nievelstein Rutger A J 29 Aug 2023, In: Pediatric radiology. 53 , p. 2492-2501 10 p.

All research output

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